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In addition, several other sites of ROS production have been identified in mammalian mitochondria, however, their direct association with hyperglycemia is still under investigation (Wong et al

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Additional research, including studies from our collaborative research groups, has shown that severe reactive astrocytes exhibit the increased production of H 2 O 2 through MAO-B, leading to AD pathology hallmarks such as tauopathy, cognitive decline and neuronal atrophy 57